598 research outputs found
Static versus dynamic fluctuations in the one-dimensional extended Hubbard model
The extended Hubbard Hamiltonian is a widely accepted model for uncovering
the effects of strong correlations on the phase diagram of low-dimensional
systems, and a variety of theoretical techniques have been applied to it. In
this paper the world-line quantum Monte Carlo method is used to study spin,
charge, and bond order correlations of the one-dimensional extended Hubbard
model in the presence of coupling to the lattice. A static alternating lattice
distortion (the ionic Hubbard model) leads to enhanced charge density wave
correlations at the expense of antiferromagnetic order. When the lattice
degrees of freedom are dynamic (the Hubbard-Holstein model), we show that a
similar effect occurs even though the charge asymmetry must arise
spontaneously. Although the evolution of the total energy with lattice coupling
is smooth, the individual components exhibit sharp crossovers at the phase
boundaries. Finally, we observe a tendency for bond order in the region between
the charge and spin density wave phases.Comment: Corrected typos. (10 pages, 9 figures
Comment on the sign of the Casimir force
I show that reflection positivity implies that the force between any mirror
pair of charge-conjugate probes of the quantum vacuum is attractive. This
generalizes a recent theorem of Kenneth and Klich to interacting quantum
fields, to arbitrary semiclassical bodies, and to quantized probes with
non-overlapping wavefunctions. I also prove that the torques on
charge-conjugate probes tend always to rotate them into a mirror-symmetric
position.Comment: 13 pages, 1 figure, Latex file. Several points clarified and
expanded, two references added
Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding
Background: The mouse has three arylamine N-acetyltransferase genes, (MOUSE)Nat1, (MOUSE)Nat2 and (MOUSE)Nat3. These are believed to correspond to (HUMAN)NAT1, (HUMAN)NAT2 and NATP in humans. (MOUSE)Nat3 encodes an enzyme with poor activity and human NATP is a pseudogene. (MOUSE)Nat2 is orthologous to (HUMAN)NAT1 and their corresponding proteins are functionally similar, but the relationship between (MOUSE)Nat1 and (HUMAN)NAT2 is less clear-cut. Methods: To determine whether the (MOUSE)NAT1 and (HUMAN)NAT2 enzymes are functionally equivalent, we expressed and purified (MOUSE)NAT1*1 and analysed its substrate specificity using a panel of arylamines and hydrazines. To understand how specific residues contribute to substrate selectivity, three site-directed mutants of (MOUSE)NAT2*1 were prepared: these were (MOUSE)NAT2_F125S, (MOUSE)NAT2_R127G and (MOUSE)NAT2_R127L. All three exhibited diminished activity towards “(MOUSE)NAT2-specific” arylamines but were more active against hydrazines than (MOUSE)NAT1*1. The inhibitory and colorimetric properties of a selective naphthoquinone inhibitor of (HUMAN)NAT1 and (MOUSE)NAT2 were investigated. Results: Comparing (MOUSE)NAT1*1 with other mammalian NAT enzymes demonstrated that the substrate profiles of (MOUSE)NAT1 and (HUMAN)NAT2 are less similar than previously believed. Three key residues (F125, R127 and Y129) in (HUMAN)NAT1*4 and (MOUSE)NAT2*1 were required for enzyme inhibition and the associated colour change on naphthoquinone binding. In silico modelling of selective ligands into the appropriate NAT active sites further implicated these residues in substrate and inhibitor specificity in mouse and human NAT isoenzymes. Conclusions: Three non-catalytic residues within (HUMAN)NAT1*4 (F125, R127 and Y129) contribute both to substrate recognition and inhibitor binding by participating in distinctive intermolecular interactions and maintaining the steric conformation of the catalytic pocket. These active site residues contribute to the definition of substrate and inhibitor selectivity, an understanding of which is essential for facilitating the design of second generation (HUMAN)NAT1-selective inhibitors for diagnostic, prognostic and therapeutic purposes. In particular, since the expression of (HUMAN)NAT1 is related to the development and progression of oestrogen-receptor-positive breast cancer, these structure-based tools will facilitate the ongoing design of candidate compounds for use in (HUMAN)NAT1-positive breast tumours. </p
Simulated responses of soil carbon to climate change in CMIP6 Earth system models: the role of false priming
Reliable estimates of soil carbon change are required to determine the carbon budgets consistent with the Paris Agreement climate targets. This
study evaluates projections of soil carbon during the 21st century in Coupled Model Intercomparison Project Phase 6 (CMIP6) Earth system models (ESMs) under a range of atmospheric composition
scenarios. In general, we find a reduced spread of changes in global soil carbon (ΔCs) in CMIP6 compared to the previous CMIP5
model generation. However, similar reductions were not seen in the derived contributions to ΔCs due to both increases in plant net primary productivity (NPP, named ΔCs,NPP) and reductions in the effective soil carbon turnover time (τs, named
ΔCs,τ). Instead, we find a strong relationship across the CMIP6 models between these NPP and τs components of
ΔCs, with more positive values of ΔCs,NPP being correlated with more negative values of
ΔCs,τ. We show that the concept of “false priming” is likely to be contributing to this emergent relationship, which leads
to a decrease in the effective soil carbon turnover time as a direct result of NPP increase and occurs when the rate of increase in NPP is
relatively fast compared to the slower timescales of a multi-pool soil carbon model. This finding suggests that the structure of soil carbon models
within ESMs in CMIP6 has likely contributed towards the reduction in the overall model spread in future soil carbon projections since CMIP5.</p
Feasibility of Electrified Propulsion for Ultra-Efficient Commercial Aircraft Final Report
MIT, Aurora Flight Sciences, and USC have collaborated to assess the feasibility of electric, hybridelectric, and turbo-electric propulsion for ultra-efficient commercial transportation. The work has drawn on the team expertise in disciplines related to aircraft design, propulsion-airframe integration, electric machines and systems, engineering system design, and optimization. A parametric trade space analysis has been carried out to assess vehicle performance across a range of transport missions and propulsion architectures to establish how electrified propulsion systems scale. An optimization approach to vehicle conceptual design modeling was taken to enable rapid multidisciplinary design space exploration and sensitivity analysis. The results of the analysis indicate vehicle aero-propulsive integration benefits enabled by electrification are required to offset the increased weight and loss associated with the electric system and achieve enhanced performance; the report describes the conceptual configurations than can offer such enhancements. The main contribution of the present work is the definition of electric vehicle design attributes for potential efficiency improvements at different scales. Based on these results, key areas for future research are identified, and extensions to the trade space analysis suitable for higher fidelity electrified commercial aircraft design and analysis have been developed
Topological semimetal in a fermionic optical lattice
Optical lattices play a versatile role in advancing our understanding of
correlated quantum matter. The recent implementation of orbital degrees of
freedom in chequerboard and hexagonal optical lattices opens up a new thrust
towards discovering novel quantum states of matter, which have no prior analogs
in solid state electronic materials. Here, we demonstrate that an exotic
topological semimetal emerges as a parity-protected gapless state in the
orbital bands of a two-dimensional fermionic optical lattice. The new quantum
state is characterized by a parabolic band-degeneracy point with Berry flux
, in sharp contrast to the flux of Dirac points as in graphene. We
prove that the appearance of this topological liquid is universal for all
lattices with D point group symmetry as long as orbitals with opposite
parities hybridize strongly with each other and the band degeneracy is
protected by odd parity. Turning on inter-particle repulsive interactions, the
system undergoes a phase transition to a topological insulator whose
experimental signature includes chiral gapless domain-wall modes, reminiscent
of quantum Hall edge states.Comment: 6 pages, 3 figures and Supplementary Informatio
Acceleressence: Dark Energy from a Phase Transition at the Seesaw Scale
Simple models are constructed for "acceleressence" dark energy: the latent
heat of a phase transition occurring in a hidden sector governed by the seesaw
mass scale v^2/M_Pl, where v is the electroweak scale and M_Pl the
gravitational mass scale. In our models, the seesaw scale is stabilized by
supersymmetry, implying that the LHC must discover superpartners with a
spectrum that reflects a low scale of fundamental supersymmetry breaking.
Newtonian gravity may be modified by effects arising from the exchange of
fields in the acceleressence sector whose Compton wavelengths are typically of
order the millimeter scale. There are two classes of models. In the first class
the universe is presently in a metastable vacuum and will continue to inflate
until tunneling processes eventually induce a first order transition. In the
simplest such model, the range of the new force is bounded to be larger than 25
microns in the absence of fine-tuning of parameters, and for couplings of order
unity it is expected to be \approx 100 microns. In the second class of models
thermal effects maintain the present vacuum energy of the universe, but on
further cooling, the universe will "soon" smoothly relax to a matter dominated
era. In this case, the range of the new force is also expected to be of order
the millimeter scale or larger, although its strength is uncertain. A firm
prediction of this class of models is the existence of additional energy
density in radiation at the eV era, which can potentially be probed in
precision measurements of the cosmic microwave background. An interesting
possibility is that the transition towards a matter dominated era has occurred
in the very recent past, with the consequence that the universe is currently
decelerating.Comment: 10 pages, references adde
Passive Maple-seed Robotic Fliers for Education, Research and Entrepreneurship
As inspirations from flora and fauna have led to many advances in modern technology, the concept of drawing ideas from nature for design should be reflected in engineering education. This paper focuses on a maple-seed robotic flier (MRF) with various complexities, a robotic platform modeled after the samaras of maple or ash trees, to teach STEM concepts to K-12 learners. Experiments using MRFs were also designed and incorporated into an undergraduate engineering course. Details are given on how the MRFs have been incorporated into K-12 camps and the undergraduate course. Unique features of MRF development are (a) very simple (using LEGOs and paper) to extremely complex (incorporation of microcontrollers and sensors) learning suitable for pre-K children, free-will adult learners, workforce training, undergraduate and graduate students, (b) research-oriented education, (c) entrepreneurship education and (d) trans-disciplinary education and research. Using microfabrication and nanofabrication technologies, the long range goal is to mass produce MRFs for surveillance in hard-to-reach and dangerous environments
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